Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)
VIP: Evidence Summary
Evidence summary for VIP across studied indications. Each indication is graded using our evidence tier system based on the quality and quantity of available clinical data.
Back to VIP overview| Indication | Evidence Tier | Trial Count | Summary |
|---|---|---|---|
| Pulmonary hypertension | Tier C | 2 | Inhaled VIP reduces pulmonary artery pressure in small trials |
| GI motility disorders | Tier C | 2 | Regulates intestinal motility and secretion; clinical applications in functional GI disorders |
| Neuroprotection | Tier D | 1 | Anti-inflammatory effects in neuroinflammation models; human data limited |
References (7)
- Overexpression of colonic VIP ameliorates cognitive function and barrier system damage caused by sevoflurane anesthesia and surgery in aged rats with fragile brain functions. — Liao H, Wang X, Yang C, Wang Z, Liu X, et al. . Experimental neurology (2025) PMID: 40456433
- Increased Expression of the Neuropeptides PACAP/VIP in the Brain of Mice with CNS Targeted Production of IL-6 Is Mediated in Part by Trans-Signalling. — Castorina A, Scheller J, Keay KA, Marzagalli R, Rose-John S, et al. . International journal of molecular sciences (2024) PMID: 39273398
- Differential Expression of PACAP/VIP Receptors in the Post-Mortem CNS White Matter of Multiple Sclerosis Donors. — Jansen MI, Musumeci G, Castorina A . International journal of molecular sciences (2024) PMID: 39201536
- Targeting the PAC1 receptor mitigates degradation of myelin and synaptic markers and diminishes locomotor deficits in the cuprizone demyelination model. — Jansen MI, Mahmood Y, Lee J, Broome ST, Waschek JA, et al. . Journal of neurochemistry (2024) PMID: 39115025
- Extracellular vesicles from primary human macrophages stimulated with VIP or PACAP mediate anti-SARS-CoV-2 activities in monocytes through NF-kB signaling pathway. — Arteaga-Blanco LA, Temerozo JR, Tiné LPS, Dantas-Pereira L, Sacramento CQ, et al. . Microbes and infection (2024) PMID: 39069117
- The impact of exogenous vasoactive intestinal polypeptide on inflammatory responses and mRNA expression of tight junction genes in lambs fed a high-grain diet. — Mia GK, Hawley E, Yusuf M, Amat S, Ward AK, et al. . Journal of animal science (2024) PMID: 39396104
- VIP in ulcerative colitis RCT. (2005) PMID: 27914657