Reviewed by Peptide Treatments Medical Advisory Board
Retatrutide: Side Effects & Safety
Known side effects, safety considerations, and adverse reaction data for Retatrutide.
Back to Retatrutide overviewData source: Side effect data comes from clinical trials, preclinical research, and anecdotal reports. No FDA-approved labeling exists for this compound.
Reported Side Effects (6 items)
| # | Side Effect |
|---|---|
| 1 | Nausea (50-60%) |
| 2 | Decreased appetite (30-40%) |
| 3 | Diarrhea (25-35%) |
| 4 | Vomiting (20-30%) |
| 5 | Constipation (15-20%) |
| 6 | Injection site reactions (5-10%) |
Known Drug Interactions
Important: Only documented and contraindicated interactions are shown here. View all interactions including theoretical →
| Drug | Classification | Mechanism |
|---|---|---|
| Insulin | Documented | Triple incretin agonist (GIP/GLP-1/glucagon) — significant hypoglycemia risk with insulin |
| Sulfonylureas | Documented | Additive hypoglycemia when combined with triple receptor agonist |