Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)
Retatrutide: Contraindications & Drug Interactions
Safety information for Retatrutide including known contraindications, drug interactions, and important precautions.
Back to Retatrutide overviewContraindications
- Personal or family history of medullary thyroid carcinoma (MTC)
- Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- History of pancreatitis
- Pregnancy and breastfeeding
- Severe gastrointestinal disease
Drug Interactions (4 interactions)
Important: This table summarizes known and theoretical interactions. Always consult a healthcare provider before combining Retatrutide with any medication.
| Drug | Classification | Mechanism |
|---|---|---|
| Insulin | Documented | Triple incretin agonist (GIP/GLP-1/glucagon) — significant hypoglycemia risk with insulin |
| Sulfonylureas | Documented | Additive hypoglycemia when combined with triple receptor agonist |
| Oral medications | Theoretical | Delayed gastric emptying may alter absorption kinetics of oral drugs |
| Other GLP-1/GIP agonists | Theoretical | Redundant mechanism — not recommended in combination |
Use our interactive Drug Interaction Checker for real-time lookup.