Reviewed by Peptide Treatments Medical Advisory Board
Liraglutide: Side Effects & Safety
Known side effects, safety considerations, and adverse reaction data for Liraglutide.
Back to Liraglutide overviewData source: These side effects are documented in FDA-approved prescribing information.
Reported Side Effects (9 items)
| # | Side Effect |
|---|---|
| 1 | Nausea (30-40%) — most common, typically diminishes over weeks |
| 2 | Vomiting (10-15%) |
| 3 | Diarrhea (15-20%) |
| 4 | Constipation (10-15%) |
| 5 | Decreased appetite (10-15%) |
| 6 | Injection site reactions (5%) |
| 7 | Pancreatitis (0.2-0.3%) — requires monitoring |
| 8 | Gallbladder disease (0.5-1%) |
| 9 | Black box warning: risk of thyroid C-cell tumors (class effect, observed in rodents) |
Known Drug Interactions
Important: Only documented and contraindicated interactions are shown here. View all interactions including theoretical →
| Drug | Classification | Mechanism |
|---|---|---|
| insulin and sulfonylureas | Documented | Additive glucose-lowering increases hypoglycemia risk — reduce insulin/sulfonylurea dose when initiating |
| oral medications (general) | Documented | Delayed gastric emptying may reduce absorption of co-administered oral drugs — separate by 1 hour |
| other GLP-1 receptor agonists | Documented | Redundant mechanism of action — do not combine |