Reviewed by Peptide Treatments Medical Advisory Board
Tirzepatide: Side Effects & Safety
Known side effects, safety considerations, and adverse reaction data for Tirzepatide.
Back to Tirzepatide overviewData source: These side effects are documented in FDA-approved prescribing information.
Reported Side Effects (7 items)
| # | Side Effect |
|---|---|
| 1 | Nausea (21-31%) |
| 2 | Diarrhea (12-22%) |
| 3 | Vomiting (8-12%) |
| 4 | Constipation (7-11%) |
| 5 | Decreased appetite (6-11%) |
| 6 | Dyspepsia (5-9%) |
| 7 | Abdominal pain (4-7%) |
Known Drug Interactions
Important: Only documented and contraindicated interactions are shown here. View all interactions including theoretical →
| Drug | Classification | Mechanism |
|---|---|---|
| Insulin | Documented | Additive hypoglycemia risk — dose reduction of insulin typically required (25-50%) |
| Sulfonylureas | Documented | Increased hypoglycemia risk — reduce sulfonylurea dose by 50% |
| Other GLP-1/GIP agonists | Documented | Additive GI effects — avoid combination |