PeptideTreatments
Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)

TB-500: Evidence Summary

Evidence summary for TB-500 across studied indications. Each indication is graded using our evidence tier system based on the quality and quantity of available clinical data.

Back to TB-500 overview
Indication Evidence Tier Trial Count Summary
Wound healing Tier C 8 Strong preclinical, limited human clinical data
Musculoskeletal recovery Tier C 5 Animal models show accelerated recovery
Cardiac repair Tier D 2 Promising preclinical, no human RCTs

References (10)

  1. Germinal peptide eye drop promotes corneal epithelial and stromal defect healing in rabbit model. . Seminars in ophthalmology (2022) PMID: 35389769
  2. Thymosin β4 released from functionalized self-assembling peptide activates epicardium and enhances repair of infarcted myocardium. . Theranostics (2021) PMID: 33754060
  3. Adjunctive Thymosin Beta-4 Treatment Influences PMN Effector Cell Function. . Cells (2021) PMID: 34944086
  4. Ethosomal Gel for Improving Transdermal Delivery of Thymosin β-4. . International journal of nanomedicine (2019) PMID: 31819429
  5. A novel dimeric thymosin beta 4 with enhanced activities accelerates the rate of wound healing. . Drug design, development and therapy (2013) PMID: 24109178
  6. Thymosin beta 4 ameliorates hyperglycemia and improves insulin resistance of KK Cg-Ay/J mouse. . Diabetes research and clinical practice (2012) PMID: 22217673
  7. A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteers. . Annals of the New York Academy of Sciences (2010) PMID: 20536472
  8. The effect of thymosin treatment of venous ulcers. . Annals of the New York Academy of Sciences (2010) PMID: 20536470
  9. Effects of thymosin beta 4 and thymosin beta 10 on actin structures in living cells. . Cell motility and the cytoskeleton (1994) PMID: 8194107
  10. Thymosin beta 4 synergizes with human granulocyte-macrophage colony-stimulating factor in maintaining bone marrow proliferation. . Immunopharmacology (1993) PMID: 8407287