Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)
Semax: Evidence Summary
Evidence summary for Semax across studied indications. Each indication is graded using our evidence tier system based on the quality and quantity of available clinical data.
Back to Semax overview| Indication | Evidence Tier | Trial Count | Summary |
|---|---|---|---|
| Stroke recovery | Tier B | 6 | Approved in Russia for cerebrovascular conditions with ~200-subject RCT |
| Cognitive enhancement | Tier C | 8 | Russian clinical trials show cognitive improvement; limited Western replication |
| Neuroprotection | Tier C | 10 | Consistent preclinical BDNF data; human outcome data limited to Russian sources |
References (9)
- Modulation of neuropathological pathways by bioactive peptides and proteins/polypeptides: Targeting oxidative stress in neurodegenerative diseases . Neuropeptides (2025) PMID: 41004910
- Semax peptide targets the mu opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice . British journal of pharmacology (2025) PMID: 40692165
- The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons . Bulletin of experimental biology and medicine (2025) PMID: 41171324
- Synthetic Adrenocorticotropic Peptides Modulate the Expression Pattern of Immune Genes in Rat Brain following the Early Post-Stroke Period . Genes (2023) PMID: 37510287
- Synthetic corticotropins and the GABA-receptor system: Direct and delayed effects . Chemical biology & drug design (2023) PMID: 36828803
- Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models . ACS chemical neuroscience (2022) PMID: 35080861
- Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats . Neuropeptides (2021) PMID: 33418449
- Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction on the Model of Social Stress . Bulletin of experimental biology and medicine (2019) PMID: 31028579
- The Use of Human Induced Pluripotent Stem Cells for Testing Neuroprotective Activity of Pharmacological Compounds . Biochemistry. Biokhimiia (2019) PMID: 31760919