Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)
PT-141: Contraindications & Drug Interactions
Safety information for PT-141 including known contraindications, drug interactions, and important precautions.
Back to PT-141 overviewContraindications
- uncontrolled hypertension
- cardiovascular disease (history of MI, stroke, CAD)
- known hypersensitivity to bremelanotide
- pregnancy (Category X)
Drug Interactions (5 interactions)
Important: This table summarizes known and theoretical interactions. Always consult a healthcare provider before combining PT-141 with any medication.
| Drug | Classification | Mechanism |
|---|---|---|
| antihypertensives | Documented | Potential additive blood pressure effects; monitor BP |
| nitrates | Documented | Risk of severe hypotension — contraindicated |
| alpha-blockers | Documented | Hypotension risk — avoid combination |
| naltrexone | Theoretical | Both affect melanocortin pathways — potential efficacy interaction |
| PDE5 inhibitors | Theoretical | Different mechanisms; potential synergy but monitor for hypotension |
Use our interactive Drug Interaction Checker for real-time lookup.