Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)
PE-22-28: Contraindications & Drug Interactions
Safety information for PE-22-28 including known contraindications, drug interactions, and important precautions.
Back to PE-22-28 overviewContraindications
- no established contraindications (zero human data)
- theoretical: seizure disorders (potassium channel modulation)
- theoretical: cardiac arrhythmias (TREK channels in cardiac tissue)
- pregnancy (no data)
Drug Interactions (3 interactions)
Important: This table summarizes known and theoretical interactions. Always consult a healthcare provider before combining PE-22-28 with any medication.
| Drug | Classification | Mechanism |
|---|---|---|
| SSRIs/SNRIs | Theoretical | Unknown interaction between serotonergic and TREK-1 potassium channel mechanisms |
| anticonvulsants | Theoretical | Possible CNS interaction through overlapping ion channel modulation |
| lithium | Theoretical | Unknown interaction — both affect CNS ion channel function |
Use our interactive Drug Interaction Checker for real-time lookup.