Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)
Orforglipron: Contraindications & Drug Interactions
Safety information for Orforglipron including known contraindications, drug interactions, and important precautions.
Back to Orforglipron overviewContraindications
- personal or family history of medullary thyroid carcinoma (MTC)
- Multiple Endocrine Neoplasia type 2 (MEN 2)
- pregnancy (category not established)
Drug Interactions (5 interactions)
Important: This table summarizes known and theoretical interactions. Always consult a healthcare provider before combining Orforglipron with any medication.
| Drug | Classification | Mechanism |
|---|---|---|
| proton pump inhibitors (omeprazole) | Documented | Elevated gastric pH reduces orforglipron Cmax by ~20% — separate dosing by 4 hours |
| antacids (calcium carbonate) | Documented | Chelation significantly reduces absorption — separate by 4 hours |
| hormonal contraceptives | Documented | Delayed gastric emptying may reduce contraceptive efficacy — take contraceptive 30 min before or 4+ hours after orforglipron |
| insulin and sulfonylureas | Documented | Additive glucose-lowering increases hypoglycemia risk — reduce sulfonylurea dose; reduce insulin by 20-30% |
| other GLP-1 receptor agonists | Documented | Duplicative therapy with no added benefit — do not combine |
Use our interactive Drug Interaction Checker for real-time lookup.