Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)
NAD+ Precursors (NMN & NR): Contraindications & Drug Interactions
Safety information for NAD+ Precursors (NMN & NR) including known contraindications, drug interactions, and important precautions.
Back to NAD+ Precursors (NMN & NR) overviewContraindications
- pregnancy and breastfeeding (limited safety data)
- active cancer (theoretical — sirtuins can affect tumor biology)
- immunosuppression
Drug Interactions (3 interactions)
Important: This table summarizes known and theoretical interactions. Always consult a healthcare provider before combining NAD+ Precursors (NMN & NR) with any medication.
| Drug | Classification | Mechanism |
|---|---|---|
| metformin | Theoretical | Possible additive NAD+-modulating effect — clinical significance unknown, monitor metabolic markers |
| rapamycin and mTOR inhibitors | Theoretical | mTOR inhibition may reduce NAD+ utilization — potential interaction with longevity stacking protocols |
| chemotherapy agents | Theoretical | NAD+ modulation could theoretically affect cancer cell metabolism — avoid during active treatment |
Use our interactive Drug Interaction Checker for real-time lookup.