Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)
Melanotan II: Side Effects & Safety
Known side effects, safety considerations, and adverse reaction data for Melanotan II.
Back to Melanotan II overviewData source: Side effect data comes from clinical trials, preclinical research, and anecdotal reports. No FDA-approved labeling exists for this compound.
Reported Side Effects (8 items)
| # | Side Effect |
|---|---|
| 1 | MELANOMA — documented case reports at injection sites |
| 2 | Nausea — common, dose-related |
| 3 | Facial flushing |
| 4 | Spontaneous erections / priapism risk (males) |
| 5 | Generalized skin darkening |
| 6 | Yawning |
| 7 | Appetite suppression |
| 8 | Systemic toxicity and rhabdomyolysis (case report) |
Known Drug Interactions
Important: Only documented and contraindicated interactions are shown here. View all interactions including theoretical →
| Drug | Classification | Mechanism |
|---|---|---|
| PDE5 inhibitors (sildenafil, tadalafil) | Documented | Additive vasodilation and erectile effects — increased risk of hypotension |