Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)

Melanotan II: Regulatory Status

Current legal and regulatory status for Melanotan II across jurisdictions. This page reflects the most recent verified information and is updated as regulatory actions occur.

Back to Melanotan II overview

United States

Research Only

Compounding status: Category 2 (restricted) — remains restricted per Feb 2026 HHS announcement. WADA: prohibited (S2 — peptide hormones). Banned for sale in Australia (TGA), UK (MHRA warnings), EU (multiple national agency warnings). Widely available through underground/grey market. Multiple deaths and hospitalizations reported to poison control centers worldwide.

Last verified:

What This Means

Reclassification is not the same as FDA approval.

Even if Melanotan II moves to Category 1, it remains an off-label therapeutic that requires physician supervision. Category 1 means it can be compounded under section 503A — it does not confer approved-drug status.

Melanotan II Overview

Uses, benefits, evidence, and monitoring.

Contraindications

Safety profile and drug interactions.

Evidence Summary

Clinical trial data and evidence tiers.