PeptideTreatments
Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)

KPV: Evidence Summary

Evidence summary for KPV across studied indications. Each indication is graded using our evidence tier system based on the quality and quantity of available clinical data.

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Indication Evidence Tier Trial Count Summary
Gut inflammation (IBD) Tier C 2 Alpha-MSH fragment reduces TNF-alpha and NF-kB in colitis models; limited human data
Antimicrobial activity Tier D 0 In vitro activity against Candida and Staphylococcus; no clinical trials

References (9)

  1. Host defense peptides as a new drug lead to a strategy for inflammatory bowel disease. . Drug discovery today (2025) PMID: 41241376
  2. KPV and RAPA Self-Assembled into Carrier-Free Nanodrugs for Vascular Calcification Therapy. . Advanced healthcare materials (2024) PMID: 39252648
  3. PepT1-targeted nanodrug based on co-assembly of anti-inflammatory peptide and immunosuppressant for combined treatment of acute and chronic DSS-induced Colitis. . Frontiers in pharmacology (2024) PMID: 39211778
  4. Are melanocortin peptides future therapeutics for cutaneous wound healing? . Experimental dermatology (2019) PMID: 30661264
  5. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. . Molecular therapy (2017) PMID: 28143741
  6. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. . Inflammatory bowel diseases (2008) PMID: 18092346
  7. Effects of the COOH-terminal tripeptide alpha-MSH(11-13) on corneal epithelial wound healing: role of nitric oxide. . Experimental eye research (2006) PMID: 16965771
  8. Three-dimensional structure of the alpha-MSH-derived candidacidal peptide [Ac-CKPV]2. . The journal of peptide research (2005) PMID: 15946192
  9. New insights into the functions of alpha-MSH and related peptides in the immune system. . Annals of the New York Academy of Sciences (2003) PMID: 12851308