PeptideTreatments
Reviewed by Peptide Treatments Medical Advisory Board

Kisspeptin-10: Research & Evidence

Emerging Evidence

Published research, clinical trial data, and evidence grading for Kisspeptin-10 across studied indications.

Back to Kisspeptin-10 overview

Research Summary

Kisspeptin is in Phase 2 development for infertility in both men and women, with 50+ human studies showing effective GnRH stimulation. MVT-602, a synthetic analog, is in active Phase 2 trials with FDA approval potentially in 2027-2028.

Evidence by Indication (3 indications)

Indication Tier Trials Summary
Reproductive function / fertility Tier B 5 Triggers LH surge for oocyte maturation; emerging alternative to hCG trigger in IVF
Hypogonadotropic hypogonadism Tier B 3 Restores pulsatile GnRH secretion in hypothalamic amenorrhea
PCOS Tier C 2 Early investigation into HPG axis modulation in polycystic ovary syndrome

Graded using our evidence tier methodology.

Research Gap Score /10

Higher score = larger gap between therapeutic potential and available clinical evidence.

Citations (11 sources)

  1. 1. Kisspeptin system-physiology and clinical perspectives. Study

    (2025), Annales d'endocrinologie

  2. 2. The silent pandemic of stress: impact on menstrual cycle and ovulation. Study

    (2025), Stress (Amsterdam, Netherlands)

  3. 3. Menopause part I: Vasomotor symptoms (I). Study

    (2025), Taiwanese journal of obstetrics & gynecology

  4. 4. The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B. Study

    (2024), Endocrine reviews

  5. 5. Sleep disturbance associated with the menopause. Study

    (2024), Menopause (New York, N.Y.)

  6. 6. Interactions between kisspeptin and bone: Cellular mechanisms, clinical evidence, and future potential. Study

    (2024), Annals of the New York Academy of Sciences

  7. 7. Jiawei Buzhong Yiqi Decoction attenuates polycystic ovary syndrome through regulating kisspeptin-GPR54-AKT-SHBG system. Study

    (2024), Phytomedicine

  8. 8. Mechanism of elevated LH/FSH ratio in lean PCOS revisited: a path analysis. Study

    (2024), Scientific reports

  9. 9. Diagnostic and therapeutic use of oral micronized progesterone in endocrinology. Study

    (2024), Reviews in endocrine & metabolic disorders

  10. 10. Polycystic ovary syndrome: pathophysiology and therapeutic opportunities. Study

    (2023), BMJ medicine

  11. 11. Kisspeptin for IVF augmentation Phase 2 trial. Clinical Trial

    (2020), Various