Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)
Kisspeptin-10: Evidence Summary
Evidence summary for Kisspeptin-10 across studied indications. Each indication is graded using our evidence tier system based on the quality and quantity of available clinical data.
Back to Kisspeptin-10 overview| Indication | Evidence Tier | Trial Count | Summary |
|---|---|---|---|
| Reproductive function / fertility | Tier B | 5 | Triggers LH surge for oocyte maturation; emerging alternative to hCG trigger in IVF |
| Hypogonadotropic hypogonadism | Tier B | 3 | Restores pulsatile GnRH secretion in hypothalamic amenorrhea |
| PCOS | Tier C | 2 | Early investigation into HPG axis modulation in polycystic ovary syndrome |
References (11)
- Kisspeptin system-physiology and clinical perspectives. . Annales d'endocrinologie (2025) PMID: 40446957
- The silent pandemic of stress: impact on menstrual cycle and ovulation. . Stress (Amsterdam, Netherlands) (2025) PMID: 39862134
- Menopause part I: Vasomotor symptoms (I). . Taiwanese journal of obstetrics & gynecology (2025) PMID: 40049806
- The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B. . Endocrine reviews (2024) PMID: 37467734
- Sleep disturbance associated with the menopause. . Menopause (New York, N.Y.) (2024) PMID: 38916279
- Interactions between kisspeptin and bone: Cellular mechanisms, clinical evidence, and future potential. . Annals of the New York Academy of Sciences (2024) PMID: 39269749
- Jiawei Buzhong Yiqi Decoction attenuates polycystic ovary syndrome through regulating kisspeptin-GPR54-AKT-SHBG system. . Phytomedicine (2024) PMID: 39116604
- Mechanism of elevated LH/FSH ratio in lean PCOS revisited: a path analysis. . Scientific reports (2024) PMID: 38589425
- Diagnostic and therapeutic use of oral micronized progesterone in endocrinology. . Reviews in endocrine & metabolic disorders (2024) PMID: 38652231
- Polycystic ovary syndrome: pathophysiology and therapeutic opportunities. . BMJ medicine (2023) PMID: 37859784
- Kisspeptin for IVF augmentation Phase 2 trial. . Various (2020) PMID: 41151445