Reviewed by Peptide Treatments Medical Advisory Board
Gonadorelin: Side Effects & Safety
Known side effects, safety considerations, and adverse reaction data for Gonadorelin.
Back to Gonadorelin overviewData source: These side effects are documented in FDA-approved prescribing information.
Reported Side Effects (7 items)
| # | Side Effect |
|---|---|
| 1 | Injection site reaction (5-10%) |
| 2 | Headache (5%) |
| 3 | Flushing (5%) |
| 4 | Nausea (<5%) |
| 5 | Ovarian hyperstimulation syndrome (2-5% in IVF context) |
| 6 | Multiple pregnancy risk (1-2% in IVF context) |
| 7 | Anaphylaxis (very rare) |
Known Drug Interactions
Important: Only documented and contraindicated interactions are shown here. View all interactions including theoretical →
| Drug | Classification | Mechanism |
|---|---|---|
| GnRH agonists (leuprolide) | Contraindicated | Causes receptor desensitization through continuous stimulation — opposes pulsatile gonadorelin effect |
| GnRH antagonists (ganirelix) | Contraindicated | Blocks GnRH receptor through competitive antagonism — prevents gonadorelin activity |
| High-dose sex steroids | Documented | Negative feedback on HPG axis may suppress pituitary response to GnRH |
| Clomiphene | Documented | Estrogen receptor modulation may interfere with HPG axis feedback |