Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)
Gonadorelin: Evidence Summary
Evidence summary for Gonadorelin across studied indications. Each indication is graded using our evidence tier system based on the quality and quantity of available clinical data.
Back to Gonadorelin overview| Indication | Evidence Tier | Trial Count | Summary |
|---|---|---|---|
| Pituitary diagnostic testing | Tier A | 50 | FDA-approved 1982; gold standard for gonadotroph function assessment |
| Hypogonadotropic hypogonadism | Tier A | 30 | 80% response rate in Phase 3 trials; FDA-approved |
| IVF protocols | Tier A | 100 | Standard of care with multiple meta-analyses |
| Fertility preservation on TRT | Tier B | 10 | Moderate evidence; widely used off-label |
References (10)
- Gonadorelin diagnostic test for pituitary function — Multiple authors . Journal of Clinical Endocrinology and Metabolism (1982) PMID: 41384863
- Treatment of hypogonadotropic hypogonadism with pulsatile GnRH — Multiple authors . Journal of Clinical Endocrinology and Metabolism (1993)
- GnRH protocols in IVF: systematic review — Multiple authors . Human Reproduction (1999) PMID: 35292717
- GnRH therapy for cryptorchidism in children — Multiple authors . Pediatrics (1994)
- GnRH agonists: gonadorelin, leuprolide and nafarelin. — Pace JN, Miller JL, Rose LI . American family physician (1991) PMID: 1835275
- Gonadotropin-releasing hormone and its analogs. — Conn PM, Crowley WF Jr . Annual review of medicine (1994) PMID: 8198390
- Assessment of gonadotropin therapy in male hypogonadotropic hypogonadism. — Ishikawa T, Ooba T, Kondo Y, et al. . Fertility and sterility (2007) PMID: 17276437
- Gonadotrophin replacement for induction of fertility in hypogonadal men. — Dwyer AA, Raivio T, Pitteloud N . Best practice & research. Clinical endocrinology & metabolism (2015) PMID: 25617175
- Outcome of gonadotropin therapy for male hypogonadotropic hypogonadism at university affiliated male infertility centers: a 30-year retrospective study. — Miyagawa Y, Tsujimura A, Matsumiya K, et al. . The Journal of urology (2005) PMID: 15879837
- [The influence of arterial partial pressure of co2 and of the arterial value of ph on endogenous catecholamines during extracorporal circulation in regard to oxygen consumption of the whole body (author's transl)]. — Schreiner-Hecheltjen J . Der Anaesthesist (1980) PMID: 6775549