Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)
GHRP-6: Evidence Summary
Evidence summary for GHRP-6 across studied indications. Each indication is graded using our evidence tier system based on the quality and quantity of available clinical data.
Back to GHRP-6 overview| Indication | Evidence Tier | Trial Count | Summary |
|---|---|---|---|
| Growth hormone secretion | Tier B | 10 | First GHRP studied in humans — robust GH release documented across multiple trials |
| Gastroprotection | Tier C | 3 | Cytoprotective effects on gastric mucosa demonstrated in animal and limited human studies |
References (10)
- Growth hormone-releasing peptide 6 (GHRP-6) hydrogel for acute kidney injury therapy via metabolic regulation. . Journal of nanobiotechnology (2025) PMID: 41327290
- Intranasal Delivery of a Ghrelin Mimetic Engages the Brain Ghrelin Signaling System in Mice. . Endocrinology (2025) PMID: 39813130
- Subchronic safety assessment of CIGB-500 in beagle dog after repeated daily dose administration over 28 days. . Regulatory toxicology and pharmacology : RTP (2025) PMID: 40024561
- Combination therapy of Epidermal Growth Factor and Growth Hormone-Releasing Hexapeptide in acute ischemic stroke: a phase I/II non-blinded, randomized clinical trial. . Frontiers in neurology (2024) PMID: 38638315
- Calorie restriction activates a gastric Notch-FOXO1 pathway to expand ghrelin cells. . The Journal of cell biology (2024) PMID: 38958606
- Ghrelin Improves Glucolipotoxicity-Induced Pancreatic beta-Cellular Dysfunction and Apoptosis by Inhibiting Endoplasmic Reticulum Stress-Induced IRE1/JNK Pathway. . Discovery medicine (2024) PMID: 39054708
- Growth hormone secretagogue peptide-6 enhances oreochromicins transcription and antimicrobial activity in tilapia. . Fish & shellfish immunology (2021) PMID: 34592474
- Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. . Translational andrology and urology (2020) PMID: 32257855
- Atheroprotective and atheroregressive potential of azapeptide derivatives of GHRP-6 as selective CD36 ligands in apolipoprotein E-deficient mice. . Atherosclerosis (2020) PMID: 32721647
- D-Lys-3-GHRP-6 impairs memory consolidation and downregulates hippocampal serotonin receptors and glutamate GluA1 subunit. . Physiology & behavior (2020) PMID: 32454141