PeptideTreatments
Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)

Epitalon: Evidence Summary

Evidence summary for Epitalon across studied indications. Each indication is graded using our evidence tier system based on the quality and quantity of available clinical data.

Back to Epitalon overview
Indication Evidence Tier Trial Count Summary
Telomere elongation Tier D 1 In vitro study shows 33% telomere elongation in cell lines; no human subject data
Anti-aging / longevity Tier D 2 Russian longitudinal studies suggest lifespan extension; limited Western replication

References (15)

  1. The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy. . Stem cell reviews and reports (2025) PMID: 40493162
  2. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. . Biogerontology (2025) PMID: 40908429
  3. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line. . International journal of molecular sciences (2022) PMID: 35408963
  4. Short Peptides Protect Oral Stem Cells from Ageing. . Stem cell reviews and reports (2020) PMID: 31677028
  5. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. . Molecules (Basel, Switzerland) (2020) PMID: 32019204
  6. [Functional regulation of genome with peptide bioregulators by hypertrophic cardiomyopathy (by patients and relatives)]. . Georgian medical news (2013) PMID: 24423684
  7. Melatonin and pineal gland peptides are able to correct the impairment of reproductive cycles in rats. . Current aging science (2012) PMID: 23237594
  8. [Characteristics of the pineal gland and thymus relationship in aging]. . Advances in gerontology = Uspekhi gerontologii (2011) PMID: 21809618
  9. [Influence of peptides from pineal gland on thymus function at aging]. . Advances in gerontology = Uspekhi gerontologii (2010) PMID: 21510076
  10. [The effect of pineal peptide preparations on proliferative activity in organotypic culture of the preoptic hypothalamus area]. . Advances in gerontology = Uspekhi gerontologii (2007) PMID: 18383712
  11. Peptides and Ageing. — Khavinson VKh . Neuro endocrinology letters (2002) PMID: 12374906
  12. Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. — Araj SK, Brzezik J, Mądra-Gackowska K, et al. . International journal of molecular sciences (2025) PMID: 40141333
  13. Peptide bioregulation of aging: results and prospects. — Anisimov VN, Khavinson VKh . Biogerontology (2010) PMID: 19830585
  14. Antioxidant properties of geroprotective peptides of the pineal gland. — Kozina LS, Arutjunyan AV, Khavinson VKh . Archives of gerontology and geriatrics (2007) PMID: 17317455
  15. Epitalon influences pineal secretion in stress-exposed rats in the daytime. — Sibarov DA, Kovalenko RI, Malinin VV, et al. . Neuro endocrinology letters (2002) PMID: 12500171