PeptideTreatments
Reviewed by Peptide Treatments Medical Advisory Board

DSIP: Research & Evidence

Early-Stage Research

Published research, clinical trial data, and evidence grading for DSIP across studied indications.

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Research Summary

DSIP's entire human evidence base consists of approximately 5 small studies from the 1980s-90s. There are no modern RCTs, zero active clinical trials, and no established human dosing or pharmacokinetics. The original sleep-enhancing claims come from rabbit studies in the 1970s. Despite popularity in biohacking circles, contemporary evidence does not support therapeutic use.

Evidence by Indication (2 indications)

Indication Tier Trials Summary
Sleep regulation Tier C 3 3-4 small, old (1980s) double-blind studies showed transient sleep improvement; no modern replication
Stress response / adaptation Tier D 1 Single uncontrolled study in withdrawal patients; primarily preclinical data

Graded using our evidence tier methodology.

Research Gap Score /10

Higher score = larger gap between therapeutic potential and available clinical evidence.

Citations (10 sources)

  1. 1. DSIP and nitrazepam sleep study in chronic insomniacs. Clinical Trial

    Schneider-Helmert (1981), Neuropsychobiology

  2. 2. Transient sleep improvement in chronic insomniacs with DSIP. Clinical Trial

    Schneider-Helmert (1989), Neuropsychobiology

  3. 3. IV DSIP in narcolepsy. Study

    Schneider-Helmert (1984), Neuropsychobiology

  4. 4. DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion. Clinical Trial

    (2021), Biomedicines

  5. 5. Phosphorylated delta sleep inducing peptide restores spatial memory and p-CREB expression by improving sleep architecture at high altitude. Study

    (2018), Life sciences

  6. 6. [Antioxidative and detoxifying effects of analogues of delta-sleep inducing peptide (DSIP)]. Study

    (2014), Bioorganicheskaia khimiia

  7. 7. [Influence of delta-sleep peptide on the enzymes activity of mitochondrial electron transport chain in various rat tissues during aging of the organism]. Study

    (2014), Advances in gerontology = Uspekhi gerontologii

  8. 8. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. Study

    (2006), Journal of neurochemistry

  9. 9. Neuropeptides and human sleep. Study

    (1997), Sleep

  10. 10. Interaction of Delta sleep-inducing peptide and valproate on metaphit audiogenic seizure model in rats. Study

    (2007), Cellular and molecular neurobiology