Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)
DSIP: Evidence Summary
Evidence summary for DSIP across studied indications. Each indication is graded using our evidence tier system based on the quality and quantity of available clinical data.
Back to DSIP overview| Indication | Evidence Tier | Trial Count | Summary |
|---|---|---|---|
| Sleep regulation | Tier C | 3 | 3-4 small, old (1980s) double-blind studies showed transient sleep improvement; no modern replication |
| Stress response / adaptation | Tier D | 1 | Single uncontrolled study in withdrawal patients; primarily preclinical data |
References (10)
- DSIP and nitrazepam sleep study in chronic insomniacs. — Schneider-Helmert . Neuropsychobiology (1981) PMID: 7028502
- Transient sleep improvement in chronic insomniacs with DSIP. — Schneider-Helmert . Neuropsychobiology (1989)
- IV DSIP in narcolepsy. — Schneider-Helmert . Neuropsychobiology (1984) PMID: 6548968
- DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion. . Biomedicines (2021) PMID: 33918965
- Phosphorylated delta sleep inducing peptide restores spatial memory and p-CREB expression by improving sleep architecture at high altitude. . Life sciences (2018) PMID: 30107169
- [Antioxidative and detoxifying effects of analogues of delta-sleep inducing peptide (DSIP)]. . Bioorganicheskaia khimiia (2014) PMID: 25898718
- [Influence of delta-sleep peptide on the enzymes activity of mitochondrial electron transport chain in various rat tissues during aging of the organism]. . Advances in gerontology = Uspekhi gerontologii (2014) PMID: 25826998
- Delta sleep-inducing peptide (DSIP): a still unresolved riddle. . Journal of neurochemistry (2006) PMID: 16539679
- Neuropeptides and human sleep. . Sleep (1997) PMID: 9456470
- Interaction of Delta sleep-inducing peptide and valproate on metaphit audiogenic seizure model in rats. . Cellular and molecular neurobiology (2007) PMID: 17957464