PeptideTreatments
Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)

Dihexa: Evidence Summary

Evidence summary for Dihexa across studied indications. Each indication is graded using our evidence tier system based on the quality and quantity of available clinical data.

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Indication Evidence Tier Trial Count Summary
Cognitive enhancement Tier D 0 Preclinical only — potent HGF/c-Met activator in animal models of cognitive decline
Neuroprotection Tier D 0 Animal studies show synaptogenesis promotion; no human trials conducted

References (10)

  1. Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats. . Journal of Huntington's disease (2024) PMID: 38489193
  2. Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy. . Stem cell research & therapy (2022) PMID: 35410439
  3. AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway. . Brain sciences (2021) PMID: 34827486
  4. Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies. . Neuroscience and biobehavioral reviews (2018) PMID: 29733881
  5. The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases. . Progress in neurobiology (2015) PMID: 25455861
  6. Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure. . Frontiers in cellular neuroscience (2015) PMID: 25674052
  7. The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer's Disease. . Journal of Alzheimer's disease : JAD (2015) PMID: 25649658
  8. The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system. . The Journal of pharmacology and experimental therapeutics (2014) PMID: 25187433
  9. Effect of structure on the interactions between five natural antimicrobial compounds and phospholipids of bacterial cell membrane on model monolayers. . Molecules (Basel, Switzerland) (2014) PMID: 24914896
  10. Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents. . The Journal of pharmacology and experimental therapeutics (2013) PMID: 23055539