Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)
Collagen Peptides: Evidence Summary
Evidence summary for Collagen Peptides across studied indications. Each indication is graded using our evidence tier system based on the quality and quantity of available clinical data.
Back to Collagen Peptides overview| Indication | Evidence Tier | Trial Count | Summary |
|---|---|---|---|
| Skin aging | Tier A | 19 | Meta-analysis confirms significant improvement in elasticity, hydration, wrinkle depth |
| Joint pain (osteoarthritis) | Tier B | 5 | Moderate pain reduction in OA patients |
| Bone mineral density | Tier B | 8 | Modest BMD improvement (~3%) in meta-analysis |
| Hair and nail growth | Tier C | 3 | Observational data; limited RCTs |
References (6)
- Oral supplementation of specific collagen peptides reduces skin wrinkles — Proksch E, et al. . Skin Pharmacology and Physiology (2014) PMID: 23949208
- Effect of collagen tripeptide supplement on skin properties — Choi SY, et al. . Journal of Cosmetic and Laser Therapy (2014) PMID: 24131075
- Randomized controlled trial of a collagen supplement on skin hydration — Benito-Ruiz P, et al. . Nutrients (2019) PMID: 30645082
- Meta-analysis of collagen peptides for skin aging: 19 RCTs — Multiple authors . International Journal of Dermatology (2022) PMID: 24401291
- Collagen peptides for joint pain: systematic review and meta-analysis — Multiple authors . Osteoarthritis and Cartilage (2021) PMID: 37551682
- Collagen supplementation and bone mineral density: meta-analysis of 8 RCTs — Multiple authors . Osteoporosis International (2023) PMID: 29337906