Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)
CJC-1295: Evidence Summary
Evidence summary for CJC-1295 across studied indications. Each indication is graded using our evidence tier system based on the quality and quantity of available clinical data.
Back to CJC-1295 overview| Indication | Evidence Tier | Trial Count | Summary |
|---|---|---|---|
| GH deficiency | Tier B | 5 | Phase II data as GHRH analog |
| Body composition | Tier C | 3 | Limited controlled data for body recomposition |
| Sleep quality | Tier D | 1 | Anecdotal and single small trial |
References (9)
- Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults — Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Bhatt R . The Journal of Clinical Endocrinology and Metabolism (2006) PMID: 16352683
- Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog — Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Storch MK, Bhatt R, Sverdloff R, Hartman ML, Veldhuis JD, Salvatori R . The Journal of Clinical Endocrinology and Metabolism (2006) PMID: 17018654
- Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog — Jette L, Leger R, Thibaudeau K, Benquet C, Robitaille M, Castaigne JP, Bhatt R . Endocrinology (2005) PMID: 15817669
- Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse — Ionescu M, Bhatt R, Gagnon C, et al. . American Journal of Physiology. Endocrinology and Metabolism (2006) PMID: 16822960
- From GHRH to IGF-1 and downstream: clinical phenotypes and biological mechanisms — Veldhuis JD, Bowers CY . Endocrinology Review (2012) PMID: 22423511
- Central and peripheral regulation of the GH/IGF-1 axis: GHRH and beyond — Multiple authors . Reviews in Endocrine and Metabolic Disorders (2024) PMID: 39579280
- Netnography of Female Use of the Synthetic Growth Hormone CJC-1295: Pulses and Potions — Grace F, Baker JS . Substance Use and Misuse (2016) PMID: 26771670
- The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects — Multiple authors . Frontiers in Endocrinology (2018) PMID: 29487568
- Analysis of growth hormone releasing hormone and its analogs in urine using nano liquid chromatography coupled with quadrupole/orbitrap mass spectrometry — Multiple authors . Journal of Pharmaceutical and Biomedical Analysis (2026) PMID: 41138283