Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)
Cerebrolysin: Evidence Summary
Evidence summary for Cerebrolysin across studied indications. Each indication is graded using our evidence tier system based on the quality and quantity of available clinical data.
Back to Cerebrolysin overview| Indication | Evidence Tier | Trial Count | Summary |
|---|---|---|---|
| Stroke recovery | Tier B | 61 | Meta-analysis shows mRS 0-1 OR 1.68 (p=0.003); 61 RCTs across stroke indications |
| Vascular dementia | Tier B | 15 | Meta-analysis shows cognitive function SMD 0.72 (p<0.0001) and improved ADL |
| Alzheimer's disease | Tier C | 10 | Moderate improvements in cognitive function; mixed results across trials |
| Traumatic brain injury | Tier C | 8 | Accelerated recovery in moderate TBI; larger confirmatory trials needed |
References (12)
- Update on Neuroprotection after Traumatic Brain Injury. . CNS drugs (2025) PMID: 40087248
- Effects of cerebrolysin on behavioral changes and the tryptophan-kynurenine pathway in the prefrontal cortex of male mice in the ketamine model of schizophrenia. . Molecular biology reports (2025) PMID: 40668305
- Cerebrolysin ameliorates ketamine-mediated anxiety and cognitive impairments via modulation of mitochondrial function and CREB/PGC-1α pathway. . Molecular brain (2025) PMID: 41204270
- Microglial Polarization and Therapeutic Strategies in Post-stroke Neuroinflammation. . Neurology and therapy (2025) PMID: 40971139
- The possible role of cerebrolysin in the management of vascular dementia: Leveraging concepts. . Neuroscience (2025) PMID: 39832667
- Efficacy analysis of neuroprotective drugs in patients with acute ischemic stroke based on network meta-analysis. . Frontiers in pharmacology (2024) PMID: 39575393
- Treatment of COVID-19 Associated Olfactory Dysfunction: A Systematic Review. . Current allergy and asthma reports (2024) PMID: 39477832
- Neuroprotective and neuroregenerative drugs after severe traumatic brain injury: A narrative review from a clinical perspective. . Wiener klinische Wochenschrift (2024) PMID: 38748062
- Current neuroprotective agents in stroke. . Turkish journal of physical medicine and rehabilitation (2024) PMID: 38948647
- Environmental enrichment and cerebrolysin improve motor and cognitive performance in a rat model of stroke. . Brain research (2024) PMID: 38048977
- Cerebrolysin for acute ischaemic stroke: a meta-analysis. . Various (2017) PMID: 28656143
- Cerebrolysin in Alzheimer's disease: a systematic review. . Various (2012) PMID: 27827552