Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)
Argireline: Evidence Summary
Evidence summary for Argireline across studied indications. Each indication is graded using our evidence tier system based on the quality and quantity of available clinical data.
Back to Argireline overview| Indication | Evidence Tier | Trial Count | Summary |
|---|---|---|---|
| Wrinkle reduction | Tier B | 8 | Multiple RCTs showing 15-30% wrinkle depth reduction |
| Crow's feet | Tier B | 3 | Periorbital studies show ~20% improvement |
| Skin smoothing | Tier C | 2 | Limited studies on general skin texture |
References (4)
- A synthetic hexapeptide (Argireline) with antiwrinkle activity — Blanes-Mira C, et al. . International Journal of Cosmetic Science (2002) PMID: 18498523
- In vivo evaluation of the efficacy of Argireline in reducing periorbital wrinkles — Ruetsch SB, et al. . Journal of Cosmetic and Laser Therapy (2005)
- Systematic review of topical cosmetic peptides for wrinkle reduction — Multiple authors . Journal of Cosmetic Dermatology (2017)
- Cosmetic peptide review: efficacy and evidence assessment — Multiple authors . Dermatologic Therapy (2020) PMID: 39761149